KMID : 0385520200330020098
|
|
Analytical Science & Technology 2020 Volume.33 No. 2 p.98 ~ p.107
|
|
Impurity profiling and chemometric analysis of methamphetamine seizures in Korea
|
|
Shin Dong-Won
Ko Beom-Jun Cheong Jae-Chul Lee Won-Ho Kim Suhk-Mann Kim Jin-Young
|
|
Abstract
|
|
|
Methamphetamine (MA) is currently the most abused illicit drug in Korea. MA is produced by chemical synthesis, and the final target drug that is produced contains small amounts of the precursor chemicals, intermediates, and by-products. To identify and quantify these trace compounds in MA seizures, a practical and feasible approach for conducting chromatographic fingerprinting with a suite of traditional chemometric methods and recently introduced machine learning approaches was examined. This was achieved using gas chromatography (GC) coupled with a flame ionization detector (FID) and mass spectrometry (MS). Following appropriate examination of all the peaks in 71 samples, 166 impurities were selected as the characteristic components. Unsupervised (principal component analysis (PCA), hierarchical cluster analysis (HCA), and Kmeans clustering) and supervised (partial least squares-discriminant analysis (PLS-DA), orthogonal partial least squares-discriminant analysis (OPLS-DA), support vector machines (SVM), and deep neural network (DNN) with Keras) chemometric techniques were employed for classifying the 71 MA seizures. The results of the PCA, HCA, K-means clustering, PLS-DA, OPLS-DA, SVM, and DNN methods for quality evaluation were in good agreement. However, the tested MA seizures possessed distinct features, such as chirality, cutting agents, and boiling points. The study indicated that the established qualitative and semi-quantitative methods will be practical and useful analytical tools for characterizing trace compounds in illicit MA seizures. Moreover, they will provide a statistical basis for identifying the synthesis route, sources of supply, trafficking routes, and connections between seizures, which will support drug law enforcement agencies in their effort to eliminate organized MA crime.
|
|
KEYWORD
|
|
methamphetamine, impurity profiling, chemometric analysis, GC-FID/MS
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|